Bio-Meso PDRN: Needle-Free Spicule Renewal — Professional 60000 & Homecare 5000

Meet GENOSYS Bio-Meso PDRN — a needle-free "liquid microneedling" treatment that uses microscopic spicules coated with PDRN to renew, regenerate and strengthen the skin. One technology, two strengths: a high-intensity professional ampoule for the clinic and a gentle homecare ampoule to maintain results between sessions.

What is spicule (bio-meso) treatment?

Spicules are microscopic, needle-like structures purified from freshwater sponges. Applied topically, they create temporary microchannels in the stratum corneum without bleeding or visible injury — also called liquid microneedling or bio-microneedling because the effect closely mimics microneedling.

• Create microchannels — tiny temporary channels that boost penetration of actives.
• Stimulate renewal — trigger fibroblast activity, collagen production and cell turnover.
• Enhance absorption — deliver PDRN and peptides deeper into the skin.
• Trigger natural exfoliation — spicules remain 24–72h, gently shedding and renewing skin.

Penetration depth is roughly 0.1–0.25 mm, controlled by spicule size and application — deep enough to stimulate, gentle enough to avoid puncturing the dermis.

PDRN + spicules: a synergy for regeneration

• Enhanced transdermal delivery — thousands of microchannels carry PDRN into the dermis where it works best.
• Regeneration support — PDRN (salmon-derived DNA) stimulates fibroblast activity and collagen/elastin synthesis.
• Less downtime — PDRN soothes inflammation and reduces redness, making treatment tolerable even for sensitive skin.
• Dual-action mechanism — spicules stimulate mechanically, PDRN supports biochemically.

Key benefits: boosts skin turnover · enhances collagen & elastin · promotes regeneration · improves skin tone · improves blemishes.

A 2-way system: Professional + Homecare

Bio-Meso PDRN Expert Ampoule 60000

Professional · 3 ml × 4 syringes · 60,000 ppm spicules

The in-clinic powerhouse. Contains a significantly higher spicule concentration than other products on the market for intensive, peel-off renewal. Equivalent to a 1.0 mm needle depth and recommended once a month.

Formulated with PDRN-coated spicules, a 9 growth-factor complex, multiple anti-aging peptides, 5 ceramides and panthenol (10,000 ppm).

View Professional Ampoule

Bio-Meso PDRN Homecare Ampoule 5000

Homecare · 50 ml · gentle daily-care concentration

The take-home companion that maintains and reinforces results between professional visits. Equivalent to a 0.25 mm needle depth and recommended once a week, in the evening.

Same Bio-Meso PDRN technology with EGF, soothing PDRN, peptides, 5 ceramides, collagen, elastin and panthenol.

View Homecare Ampoule

Professional vs. Homecare at a glance

How to use

Professional (Expert 60000)

After cleansing and prep, protect the eyes with wet cotton pads and apply the full 3 ml on the face (avoid eyes and lips). Spread evenly, press the spicules in with palms/fingers, then massage with a rolling motion. To calm the skin, finish with the Skin Reboot PDRN Mask Pack (10–15 min) or, for sensitive skin, the Bio Ferment Age-Defying Mask (~20 min). Interval: 3–4 weeks.

Homecare (Homecare 5000)

In the evening, after cleansing, apply about 3 ml on the face. Spread evenly, press into the treatment area with palms/fingers, then massage in a rolling motion for ~30 seconds. To calm the skin, apply the Skin Reboot PDRN Mask Pack for 10–15 minutes. Use once a week.